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ReGen Therapeutics

Hair loss in women is incredibly common, but that does not make it any less emotional. I always tell women that hair is not “just hair.” It is tied to confidence, femininity, stress, hormones, health, and how we see ourselves in the mirror. The good news is that once we understand why the hair is thinning or shedding, we can usually put together a much smarter plan than simply guessing or buying the latest product online.

1. What exactly is hair loss, and how is normal shedding different from true hair loss?

I explain it this way: normal shedding is part of the hair cycle. Hair grows, rests, sheds, and then new hair should come in behind it. Most women lose some hair every day, especially in the shower, on the brush, or on the pillow. That can look scary, but it can still be normal.
True hair loss is different. That is when the balance changes. Either too many hairs are being pushed into the shedding phase, or the follicle itself starts producing thinner, weaker hair. In female pattern hair loss, for example, the follicle miniaturizes. That means the hair strand gets smaller in diameter, the part looks wider, the ponytail feels thinner, and the scalp becomes more visible.
So, when I see a woman, I am not only asking, “Are you shedding?” I am asking, “Are the hairs coming back as strong as they used to?” That is the key difference. Shedding can be temporary. Follicle weakening and miniaturization can become progressive if we do not address it early.

2. What are the top 5 causes of hair loss in women?

There are many possible causes, but these are the five I see and think about most often.

1. Female pattern hair loss / androgenetic alopecia

This is the most common long-term type of thinning in women. It is usually genetic and hormone- influenced. Women often do not go bald like men, but they notice a widening part, less volume on top, and more scalp showing under bright lights.
What is happening biologically is that certain follicles become sensitive to androgens, especially DHT. DHT can shrink the follicle over time. The hair does not necessarily fall out all at once; it becomes finer and weaker with each growth cycle. That is why I like to treat it early, before the follicles become too miniaturized.

2. Telogen effluvium / stress shedding

This is very common in women and it is often sudden. A woman may say, “My hair is coming out by the handful.” It can happen after illness, surgery, a high fever, severe emotional stress, rapid weight loss, childbirth, a major diet change, or certain medications.
The stressor pushes too many hairs out of the growth phase and into the resting/shedding phase. The tricky part is that the shedding often shows up two or three months after the trigger, so women do not always connect the dots. This type can improve, but the body has to be stabilized nutritionally and hormonally, and the scalp has to be supported.

3. Menopause and hormone changes

Midlife is a very common time for women to notice thinning. Estrogen helps support the hair growth cycle, and when estrogen drops during perimenopause and menopause, hair can spend less time in the growing phase. At the same time, the relative effect of androgens can become more noticeable.
That combination can lead to slower growth, finer strands, a wider part, and more breakage. I tell women not to dismiss this as “just aging.” Hormones are part of the story, but so are nutrition, inflammation, stress, thyroid function, scalp health, and genetics.

4. Nutrient deficiencies and metabolic stress

Hair is not essential for survival, so when the body is under stress or low in nutrients, hair is one of the first things to suffer. Low iron or ferritin, low vitamin D, low protein intake, poor absorption, thyroid issues, and aggressive dieting can all affect hair.
This is especially important now because many women are losing weight quickly, including with GLP-1 weight-loss medications. Weight loss can be wonderful for health when it is done correctly, but if protein, minerals, essential fats, and overall nutrition drop too low, the hair may pay the price. I always want women to lose weight in a way that protects the hair, not sacrifices it.

5. Autoimmune, inflammatory, and mechanical causes

Alopecia areata is autoimmune and can cause round patches of hair loss. Scalp inflammation, dandruff, psoriasis, seborrheic dermatitis, and some scarring alopecias can also interfere with follicle function. Tight hairstyles, extensions, braids, and repeated pulling can cause traction alopecia.
The common thread is that the follicle is being attacked, inflamed, or physically stressed. The earlier these are identified, the better. Once scarring occurs, regrowth becomes much harder, so women should not wait months or years if they see patches, pain, burning, scaling, or a receding hairline from tension.

3. What is the connection between menopause and hair loss?

Menopause and hair loss are connected mainly through hormone changes, but it is not just one hormone. Estrogen tends to support a longer growth phase for hair. When estrogen declines, the growth phase can shorten and hair may become finer. At the same time, androgens may have a stronger relative effect, and in women who are genetically sensitive, that can contribute to follicle miniaturization.
This is why so many women say, “My hair changed in my 40s or 50s.” The ponytail is smaller, the part is wider, and the texture is not the same. I also see that midlife often comes with more stress, sleep disruption, thyroid changes, dieting, medications, and lower nutrient reserves. So, in my opinion, menopause can open the door, but the whole body usually explains why the hair is struggling.

4. What is Traditional Chinese Medicine (TCM), and how has it historically approached hair loss?

Traditional Chinese Medicine is a very old healing system that looks at the body as a whole, not just one symptom. It includes herbs, acupuncture, nutrition, lifestyle practices, massage, tai chi, and qi gong. In TCM thinking, hair health has traditionally been connected to the strength of the blood, the kidneys, the liver, circulation, and overall vitality.
Now, I am not a TCM doctor, so I am careful not to pretend every traditional explanation matches modern physiology word for word. But I do appreciate the concept of looking beyond the scalp. Modern hair science agrees with that part. Hair loss can be driven by hormones, inflammation, nutrition, circulation, stress, immune activity, and follicle signaling. TCM has historically tried to support the terrain of the body, not just cover up the symptom.

5a. What is Polygonum multiflorum?

Polygonum multiflorum is a traditional Chinese medicinal root, also known as He Shou Wu or Fo-Ti. The newer botanical name often used is Pleuropterus multiflorus. Historically, it has been used in Chinese medicine for aging, vitality, graying hair, and hair thinning. In hair discussions, it has become especially interesting because it appears to work through several pathways at once, at least in laboratory and early research models.
The important thing I would say to readers is this: natural does not automatically mean safe, and traditional does not automatically mean proven. Polygonum multiflorum is one of the more interesting herbs for hair biology, but it also has very real safety concerns when taken internally.

5b. What explains these results? How might Polygonum multiflorum support hair growth?

The review in the Journal of Holistic Integrative Pharmacy is interesting because it does not describe Polygonum multiflorum as working in just one way. The authors reviewed evidence suggesting it may support hair growth through several mechanisms.
  • DHT and enzyme activity: In androgenetic alopecia, DHT is one of the major hormones associated with follicle miniaturization. Some research suggests compounds in Polygonum multiflorum may help influence pathways connected to DHT and 5-alpha reductase activity.
  • Follicle cell protection: Hair follicles are living mini-organs. If follicle cells are under oxidative or inflammatory stress, growth can suffer. The herb has been studied for antioxidant and cell-protective effects that may help reduce follicle cell damage or premature cell death.
  • Growth signaling: Hair growth depends on signaling pathways that tell the follicle to stay active and regenerate. The review discusses pathways such as Wnt and Sonic hedgehog, which are involved in follicle activation and regeneration.
  • Growth factors: Research discussed in the review suggests Polygonum multiflorum may influence growth-supporting factors such as IGF-1, HGF, VEGF, and other factors involved in the follicle environment.
  • Scalp circulation: A follicle needs oxygen, nutrients, and blood flow. The review also discusses effects on microcirculation, blood rheology, and delivery of nutrients to the scalp environment.
In plain English, I would explain it to women this way: the herb may be helpful because it appears to support the follicle from several angles: hormone signaling, inflammation, cell survival, growth activation, and circulation. That multi-target approach is why it is getting attention. But I would still call the evidence promising, not conclusive. We need better human clinical trials before anyone should treat it like a guaranteed hair-loss solution.

5c. Are there safety concerns, side effects, interactions, or risks?

Yes, and this is where I would be very clear. Polygonum multiflorum has been linked to liver injury. That does not mean every person who takes it will have a problem, but the risk is real enough that I would not recommend women casually buying it online and taking it without professional guidance.
Reported side effects can include nausea, abdominal pain, diarrhea, vomiting, fatigue, dark urine, jaundice, and abnormal liver enzymes. The more serious concern is drug-induced liver injury, which in rare cases can be severe. Risk may be higher with high doses, long-term use, poor-quality products, alcohol use, existing liver disease, or combining it with other medications or supplements that stress the liver.
Women should be especially cautious if they are pregnant, breastfeeding, have liver disease, have hepatitis, drink alcohol regularly, take cholesterol medications, acetaminophen frequently, antifungals, seizure medications, blood thinners, hormone therapies, chemotherapy drugs, or multiple prescriptions. They should also tell their physician about any herb they are taking, because herbs can interact with medications.
My practical advice: if a woman is interested in Polygonum multiflorum, she should work with a qualified practitioner, use a reputable product, avoid mega-dosing, avoid combining it with alcohol or other liver- stressing products, and consider liver-function monitoring. And if she develops yellowing of the skin or eyes, dark urine, severe fatigue, nausea, or right-sided abdominal pain, she should stop it and seek medical care immediately.

6. Four other natural TCM-inspired herbs, ingredients, or practices that may help support healthy hair growth

1. Rehmannia root / Shu Di Huang

What it is: Rehmannia is a traditional Chinese herb often used in formulas aimed at nourishing yin, blood, and kidney energy in TCM language.
How it may support hair: From a modern perspective, it is often discussed for antioxidant and anti- inflammatory activity and for its use in formulas that support overall vitality. Since hair follicles are sensitive to inflammation, oxidative stress, and nutritional depletion, this is one reason it appears in traditional hair formulas.
Evidence: Most of the evidence is traditional-use based, formula-based, or preclinical. I would not present it as a stand-alone proven hair-growth drug, but as an ingredient that may be part of a broader TCM-style support plan.

2. Ligustrum lucidum / Nu Zhen Zi

What it is: Nu Zhen Zi is the fruit of Ligustrum lucidum and is commonly used in TCM formulas, including formulas historically aimed at hair graying and weakness.
How it may support hair: It is traditionally used to support liver and kidney yin. In modern terms, it has been studied for antioxidant and immune-modulating properties, which may be relevant because oxidative stress and inflammation can affect follicle function.
Evidence: The strongest support is traditional use and early laboratory research, not large modern hair- loss trials. I would consider it supportive, not definitive.

3. Ginseng / Ren Shen or Panax ginseng

What it is: Ginseng is one of the best-known herbs in Asian medicine. It is considered an adaptogenic herb, meaning it is often used to help the body respond to stress.
How it may support hair: Stress can push hair into the shedding phase, and some compounds in ginseng have been studied for effects on dermal papilla cells, inflammation, and hair-cycle signaling. It may also help indirectly by supporting energy and stress resilience.
Evidence: There is some preclinical and small clinical interest in ginseng-related compounds for hair biology, but I would still say the evidence is developing. It should also be used carefully because it may interact with blood thinners, diabetes medications, stimulants, and blood pressure medications.

4. Acupuncture and scalp-focused circulation practices

What it is: Acupuncture is a TCM practice using very thin needles at specific points. Some practitioners also use scalp acupuncture, gentle scalp massage, gua sha-style techniques, or microcirculation- focused approaches.
How it may support hair: The idea is to improve circulation, reduce stress, calm inflammation, and support the nervous system. Since stress and circulation both matter for hair, I can understand why some women are interested in it.
Evidence: Evidence for acupuncture specifically for hair loss is still limited and mixed, but acupuncture may help some people with stress, pain, and overall wellbeing. For hair loss, I would call it an adjunct, not a replacement for diagnosis or proven medical treatment. It should be performed by a licensed practitioner using sterile needles.

7. Anything else readers should know about TCM approaches to hair loss and scalp health?

The biggest message I would give Woman’s World readers is not to think of TCM as “magic herbs” and not to think of conventional medicine as the only answer either. The best approach is often integrative. We want to identify the cause, protect the follicle, reduce inflammation, support nutrition, manage stress, and improve the scalp environment.
I also want women to be careful. Hair loss makes people vulnerable. When a woman is scared, she may buy anything that promises regrowth. But herbs can be powerful, and poor-quality supplements can be contaminated or mislabeled. So I prefer professional guidance, especially if a woman is taking medications, has liver or kidney disease, is pregnant, is breastfeeding, or has autoimmune disease.
Finally, I always remind women that early action matters. If the part is widening, the ponytail is shrinking, or shedding is lasting more than a few months, do not just wait and hope. Get evaluated. Check thyroid, iron/ferritin, vitamin D, protein intake, hormone changes, medications, stress, and scalp inflammation. Hair loss is rarely one single thing. When we treat the whole person and the follicle together, we usually have a much better chance of helping the hair recover.

Sources

Han B, Xiao M, Xin T, et al. “Research progress on the application of Pleuropterus multiflorus in the treatment of androgenetic alopecia.” Journal of Holistic Integrative Pharmacy. 2025;6(4):443-453. DOI: 10.1016/j.jhip.2025.12.005.
LiverTox, National Institute of Diabetes and Digestive and Kidney Diseases / National Library of Medicine. “Polygonum Multiflorum.” Updated August 18, 2020.
National Center for Complementary and Integrative Health. “Traditional Chinese Medicine: What You Need To Know.”
American Academy of Dermatology Association. Hair Loss Resource Center and Female Pattern Hair Loss patient information.
Cleveland Clinic. Female Pattern Baldness and Hair Loss in Women patient information.
Hughes EC, Saleh D. “Telogen Effluvium.” StatPearls / NCBI Bookshelf. Updated 2024.
Huang Z, et al. “Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-review.” Frontiers in Pharmacology. 2025.